The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels
نویسندگان
چکیده
منابع مشابه
Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.
BACKGROUND AND OBJECTIVES Phenytoin, a widely used anti-epileptic drug, is metabolized mainly by CYP2C9 (90%) and partly by CYP2C19 (10%) to its major metabolite 5-(para-hydroxyphenyl)-5- phenylhydantoin (p-HPPH). The CYP2C9 and CYP2C19 genes encoding these enzymes are polymorphically expressed and most of the variants result in decreased metabolism of the respective substrates. The present stu...
متن کاملThe role of CYP2C9 polymorphisms in phenytoin-related cerebellar atrophy
PURPOSE Phenytoin is known to be able to induce cerebellar atrophy in patients with epilepsy. It is also known that a CYP2C9 mutation (*2 or *3) reduces phenytoin metabolism by 25-50% and can increase the risk of phenytoin-related side effects. We examined the influence of CYP2C9 polymorphisms on total cerebellar volume and cerebellar gray and white matter volumes in patients with epilepsy taki...
متن کاملCYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.
The commonly prescribed antiepileptic drug phenytoin has a narrow therapeutic range and wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 coding variants. After finding a paradoxically low urinary phenytoin metabolite (S)/(R) ratio in subjects receiving phenytoin maintenance therapy with a CYP2C9*1/*1 and CYP2C19*1/*2 genotype, we hypothesized that CYP2C9 reg...
متن کاملfrequency distribution of polymorphisms of cyp2c19, cyp2c9, vkorc1 and slco1b1 genes in the yakut population
allele frequencies of single nucleotide polymorphisms (snps) are variable among different populations; therefore the study of snps in ethnic groups is important for establishing the clinical significance of the screening of these polymorphisms. the main goal of the research is to study the polymorphisms of cyp2c9 , cyp2c19 , vkorc1 , and slco1b1 in yakuts. genomic dna from 229 yakut subjects we...
متن کاملEffect of Pioglitazone on Plasma Levels of Phenytoin in Rats
Introduction: Interaction between drugs represents a major clinical concern for health care professionals and their patients. Patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin concurrently. The aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. According to t...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2001
ISSN: 1470-269X,1473-1150
DOI: 10.1038/sj.tpj.6500025